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The abnormally high expression of glutathione transferases is closely associated with cancer incidence and drug resistance. By introducing a hydrophobic moiety to the inhibitor structure, we organized a series of… Click to show full abstract
The abnormally high expression of glutathione transferases is closely associated with cancer incidence and drug resistance. By introducing a hydrophobic moiety to the inhibitor structure, we organized a series of degraders of glutathione transferases and demonstrated them potently inducing apoptosis in cancer cells, presenting their pharmacological potential in cancer therapy.
Keywords:
inhibitor;
apoptosis cancer;
induction apoptosis;
cancer cells;
cancer
Journal Title: ACS medicinal chemistry letters
Year Published: 2021
Link to full text (if available)
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Journal Title: ACS medicinal chemistry letters
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!