This highlight presents novel 6-aryl isoindolin-1-one derivatives that developed as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 2 (mGluR2). Chemical synthesis and potency (IC50) data for both mGluR2 and… Click to show full abstract
This highlight presents novel 6-aryl isoindolin-1-one derivatives that developed as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 2 (mGluR2). Chemical synthesis and potency (IC50) data for both mGluR2 and mGluR3 are disclosed.
Keywords:
allosteric modulators;
negative allosteric;
aryl isoindolin;
ones novel;
novel mglur2;
isoindolin ones
Journal Title: ACS medicinal chemistry letters
Year Published: 2025
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Journal Title: ACS medicinal chemistry letters
Year Published: 2025
Link to full text (if available)
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recommendations!