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Human immunodeficiency virus (HIV) infections and related diseases remain as major public health problems worldwide. The replication of HIV type 1 (HIV-1) requires the actions of three essential enzymes: reverse… Click to show full abstract
Human immunodeficiency virus (HIV) infections and related diseases remain as major public health problems worldwide. The replication of HIV type 1 (HIV-1) requires the actions of three essential enzymes: reverse transcriptase, protease, and integrase. There are many effective and widely used drugs that target reverse transcriptase and protease. These drugs are particularly useful and more effective when taken in combination; however, toxicity and development of resistant virus strains have limited their usefulness. Accordingly, there is a need to develop new drugs that inhibit the replication of resistant HIV without toxicity issues.
Journal Title: ACS medicinal chemistry letters
Year Published: 2017
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