LAUSR

The controlled fabrication of spatial architectures using metal-organic framework (MOF)-based particles offers opportunities for enhancing photocatalytic performances. The understanding of the contribution of assembly to a precise photocatalytic mechanism, particularly from the perspective of charge separation and extraction dynamics, still poses challenges. The present report presents a facile approach for the spatial assembly of zinc imidazolate MOF (ZIF-8), guided by β-turn peptides (SAZH). We investigated the dynamics of photoinduced carriers using transient absorption spectroscopy. The presence of a long-lived internal charge-separated state in SAZH confirms its role as an intersystem crossing state. The formation of an assembly interface facilitates efficient electron transfer from SAZH to O2, resulting in approximately 2.6 and 2 times higher concentrations of superoxide (·O2-) and hydrogen peroxide (H2O2), respectively, compared to those achieved with ZIF-8. The medical dressing fabricated from SAZH demonstrated exceptional biocompatibility and exhibited an outstanding performance in promoting wound restoration. It rapidly achieved hemostasis during the bleeding phase, followed by a nearly 100% photocatalytic killing efficiency against the infected site during the subsequent inflammatory phase. Our findings reveal a pivotal dynamic mechanism underlying the photocatalytic activity of control-assembled ZIF-8, providing valuable guidelines for the design of highly efficient MOF photocatalysts.