This study describes the solvent and catalyst-free Ugi reaction by way of twin screw extrusion (TSE). Multicomponent chemical synthesis can be converted into a single process without repeated use of… Click to show full abstract
This study describes the solvent and catalyst-free Ugi reaction by way of twin screw extrusion (TSE). Multicomponent chemical synthesis can be converted into a single process without repeated use of solvents through TSE. High synthetic yields are achieved in short reaction times and produced in solvent-free conditions, which lead to a more environmentally friendly process.
               
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