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Polycyclic spiro lignans are a new family of lignan natural products recently isolated from Gymnotheca involucrata. The first synthesis of two model substrates of this rare family of natural products… Click to show full abstract
Polycyclic spiro lignans are a new family of lignan natural products recently isolated from Gymnotheca involucrata. The first synthesis of two model substrates of this rare family of natural products was achieved in six steps. An efficient strategy that features Suzuki coupling and Friedel–Crafts acylation was employed to construct the ABC tricyclic fluorene framework. Subsequently, Grignard reaction followed by acid-mediated cyclization furnished the spiro cyclic ether ring D.
Keywords:
lignan natural;
framework;
natural products;
synthesis tetracyclic;
polycyclic spiro
Journal Title: ACS Omega
Year Published: 2020
Link to full text (if available)
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Journal Title: ACS Omega
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!