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Here, a large-scale feasible, chromatography-free process to purge triphenylphosphine oxide (TPPO) from the crude product of Mitsunobu and Wittig reactions has been developed. Divergence in physicochemical properties like polarity and… Click to show full abstract
Here, a large-scale feasible, chromatography-free process to purge triphenylphosphine oxide (TPPO) from the crude product of Mitsunobu and Wittig reactions has been developed. Divergence in physicochemical properties like polarity and solubility of TPPO against the product was utilized to precipitate TPPO directly from the reaction mixture and eliminate by simple filtration on a kilogram scale at a pilot plant with high purity of the product.
Keywords:
triphenylphosphine oxide;
removal reactions;
role solvent;
oxide removal;
reactions role;
triphenylphosphine
Journal Title: ACS Omega
Year Published: 2021
Link to full text (if available)
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Journal Title: ACS Omega
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!