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Garland, Flower, and Petals via a Hierarchical Self-Assembly of Ursane-Type Triterpenoid Uvaol

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Uvaol, a 6-6-6-6-6 pentacyclic dihydroxy ursane-type triterpenoid, is isolable from different parts of plants Plumeria rubra, Olea europaea, Nerium oleander, Lavandula pedunculta, and Malus domestica. It is also obtained by… Click to show full abstract

Uvaol, a 6-6-6-6-6 pentacyclic dihydroxy ursane-type triterpenoid, is isolable from different parts of plants Plumeria rubra, Olea europaea, Nerium oleander, Lavandula pedunculta, and Malus domestica. It is also obtained by a one-step reduction of naturally occurring triterpenoid ursolic acid. Herein, we report the first self-assembly properties of uvaol in different neat organic liquids and aqueous organic binary liquid mixtures. Spontaneous self-assembly of uvaol in different neat liquids and binary liquid mixtures yielded garland, flower, and petal-like porous superstructures of nano- to micrometer dimensions. Utilization of self-assemblies has been demonstrated in generation of anticancer drug conjugates and the removal of carcinogenic and toxic chemicals.

Keywords: ursane type; self assembly; self; type triterpenoid; garland flower

Journal Title: ACS Omega
Year Published: 2021

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