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Electrochemical [4 + 1] Tandem sp3(C–H) Double Amination for the Direct Synthesis of 3-Acyl-Functionalized Imidazo[1,5-a]pyridines

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3-Acyl imidazo[1,5-a]pyridines, featured pharmaceutical moieties that were prepared by a three-step reaction conventionally, could be obtained in one step by an electrochemical tandem sp3 (C–H) double amination of acetophenones with… Click to show full abstract

3-Acyl imidazo[1,5-a]pyridines, featured pharmaceutical moieties that were prepared by a three-step reaction conventionally, could be obtained in one step by an electrochemical tandem sp3 (C–H) double amination of acetophenones with pyridine ethylamines using ammonium iodide as a redox mediator.

Keywords: imidazo pyridines; tandem sp3; sp3 double; double amination; acyl; electrochemical tandem

Journal Title: ACS Omega
Year Published: 2022

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