A synthetic strategy to pyrrolo[2,1-f][1,2,4]triazines is reported. We show that various synthetically easily accessible 1,2,4-triazines can be efficiently alkylated under mild conditions to provide the corresponding 1-alkyl-1,2,4-triazinium salts. These bench-stable… Click to show full abstract
A synthetic strategy to pyrrolo[2,1-f][1,2,4]triazines is reported. We show that various synthetically easily accessible 1,2,4-triazines can be efficiently alkylated under mild conditions to provide the corresponding 1-alkyl-1,2,4-triazinium salts. These bench-stable salts serve as precursors to triazinium ylides, which react in 1,3-dipolar cycloadditions with electron-poor dipolarophiles to yield polysubstituted pyrrolotriazines in a single step.
Keywords:
regio diastereoselective;
triazin ium;
diastereoselective dipolar;
cycloadditions triazin;
pyrrolo triazines;
dipolar cycloadditions
Journal Title: ACS Omega
Year Published: 2022
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Journal Title: ACS Omega
Year Published: 2022
Link to full text (if available)
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recommendations!