Photo by paipai90 from unsplash
A late-stage functionalization (LSF) of the natural product andrographolide for the efficient assembly of a range of structurally interesting and diverse tricyclic-aza derivatives was developed. The key to the diversification… Click to show full abstract
A late-stage functionalization (LSF) of the natural product andrographolide for the efficient assembly of a range of structurally interesting and diverse tricyclic-aza derivatives was developed. The key to the diversification is a photo-catalyzed intramolecular hydroamination reaction, and acridinium derivatives were demonstrated to be the optimal catalysts. Additionally, the synthesized tricyclic aza-andrographolide derivatives were found to inhibit human coronavirus with high potency.
Keywords:
andrographolide derivatives;
human coronavirus;
tricyclic aza;
late stage;
aza andrographolide
Journal Title: ACS Omega
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: ACS Omega
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!