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The present article discloses an improved and robust commercial process of the modern medicine naloxegol oxalate, which is used to treat opioid-induced constipation. The synthesis originates from the easily available… Click to show full abstract
The present article discloses an improved and robust commercial process of the modern medicine naloxegol oxalate, which is used to treat opioid-induced constipation. The synthesis originates from the easily available key starting material, viz., naloxone, and ends with the oxalate salt of naloxegol (a pharmaceutically acceptable salt). This novel route has a very high yield and purity greater than 99.5%, substantially free from impurities (less than 1%).
Keywords:
oxalate opiod;
preparation naloxegol;
improved process;
naloxegol;
naloxegol oxalate;
process preparation
Journal Title: ACS Omega
Year Published: 2023
Link to full text (if available)
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Journal Title: ACS Omega
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!