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The cobalt(III)-catalyzed site-selective C-2 functionalization of indole has been developed using the pyrimidinyl group as a directing group. This reaction furnishes 3-arylated succinimide derivatives in excellent yields in a shorter… Click to show full abstract
The cobalt(III)-catalyzed site-selective C-2 functionalization of indole has been developed using the pyrimidinyl group as a directing group. This reaction furnishes 3-arylated succinimide derivatives in excellent yields in a shorter duration using an inexpensive Co catalyst. Highly selective C-2 functionalization of indoles was achieved in the presence of the highly reactive C-3 position. This protocol is compatible with a variety of N-pyrimidinyl indole and maleimide derivatives, and it can be easily scaled-up. This method is also applicable for maleic ester and heteroarenes.
Journal Title: ACS Omega
Year Published: 2017
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