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Water is an ideal solvent for chemical transformations in environmentally friendly and sustainable processes. An operationally simple, metal-free, and green approach to the synthesis of oxindole-fused spirotetrahydrofurans from 3-allyl-3-hydroxy-2-oxindoles in… Click to show full abstract
Water is an ideal solvent for chemical transformations in environmentally friendly and sustainable processes. An operationally simple, metal-free, and green approach to the synthesis of oxindole-fused spirotetrahydrofurans from 3-allyl-3-hydroxy-2-oxindoles in water is described. This method requires only cheap methanesulfonic acid as a catalyst and eliminates the need of complicated reagents. This atom- and step-economical transformation is highly efficient, which provides a new approach for the construction of oxindole-fused spirotetrahydrofuran molecules with potential pharmaceutical interest.
Journal Title: ACS Omega
Year Published: 2017
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