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Efficient New Protocols for Converting Primary Amides into Nitriles Initiated by P(NMe2)3, PCl3, or P(OPh)3

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Three efficient and high-yielding procedures have been developed for the conversion of primary amides into nitriles, mediated by hitherto unexplored P(NMe2)3, PCl3, or P(OPh)3. The reactions were conducted under operationally… Click to show full abstract

Three efficient and high-yielding procedures have been developed for the conversion of primary amides into nitriles, mediated by hitherto unexplored P(NMe2)3, PCl3, or P(OPh)3. The reactions were conducted under operationally simple and mild conditions and displayed broad substrate scope and good functional group tolerance.

Keywords: efficient new; pcl3 oph; nme2 pcl3; amides nitriles; primary amides

Journal Title: ACS Omega
Year Published: 2018

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