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A mechanism for the formation of pantoprazole related compound E (RC E) is proposed involving the formation of a radical cation in the pH range of 5–8. pH dependence of… Click to show full abstract
A mechanism for the formation of pantoprazole related compound E (RC E) is proposed involving the formation of a radical cation in the pH range of 5–8. pH dependence of RC E is demonstrated, and the contribution of the difluoromethoxy group in stabilizing the C-6 free radical, a prerequisite to the formation of the dimer byproduct, is discussed. Also, the synthesis of pantoprazole RC E is reported using the benzidine rearrangement.
Keywords:
mechanism formation;
synthesis pantoprazole;
related compound;
formation
Journal Title: ACS Omega
Year Published: 2019
Link to full text (if available)
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Journal Title: ACS Omega
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!