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The three-component coupling reaction of 1,1-dibromoalkenes 1, vinylzinc chloride 2, and carbon soft nucleophiles 3 was realized in the presence of the catalytic palladium/Xantphos species, and 1,3-disubstituted allenic products 5… Click to show full abstract
The three-component coupling reaction of 1,1-dibromoalkenes 1, vinylzinc chloride 2, and carbon soft nucleophiles 3 was realized in the presence of the catalytic palladium/Xantphos species, and 1,3-disubstituted allenic products 5 were obtained in yields of up to 77%. The successive two palladium-catalyzed processes, namely the cross-coupling reaction and the allylic substitution, assembled 5 from the easily accessible starting compounds.
Keywords:
soft nucleophiles;
component coupling;
dibromoalkenes vinylzinc;
three component;
vinylzinc chloride;
palladium
Journal Title: ACS Omega
Year Published: 2019
Link to full text (if available)
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Journal Title: ACS Omega
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!