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5-Fluorouracil-nicotinamide (5-FU-NCM), a co-crystal with a 2D layer structure formed by hydrogen bonds, was synthesized by solvent evaporation and liquid phase-assisted grinding at room temperature. Compared to 5-FU alone, the… Click to show full abstract
5-Fluorouracil-nicotinamide (5-FU-NCM), a co-crystal with a 2D layer structure formed by hydrogen bonds, was synthesized by solvent evaporation and liquid phase-assisted grinding at room temperature. Compared to 5-FU alone, the results of solubility, oil–water partition coefficient, anti-tumor effect in vivo and vitro, acute toxicity, and pharmacokinetic parameters indicate that the co-crystal is a potential anti-tumor drug.
Keywords:
potential anti;
tumor drug;
anti tumor;
fluorouracil nicotinamide;
tumor
Journal Title: ACS Omega
Year Published: 2020
Link to full text (if available)
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Journal Title: ACS Omega
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!