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A convenient method of synthesis has been developed for a new class of potential cooling agents, menthol glycinates. These compounds are prepared in two synthetic steps, starting from bromoacetyl bromide… Click to show full abstract
A convenient method of synthesis has been developed for a new class of potential cooling agents, menthol glycinates. These compounds are prepared in two synthetic steps, starting from bromoacetyl bromide and (−)-menthol. The resulting brominated menthol ester readily undergoes substitution reactions with NH3 and 1° or 2° amines to provide menthol glycinates. For most of the prepared compounds, the two-step synthetic procedure requires no aqueous phase extractions.
Keywords:
menthol glycinates;
glycinates potential;
cooling agents;
potential cooling;
menthol;
synthesis menthol
Journal Title: ACS Omega
Year Published: 2020
Link to full text (if available)
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Journal Title: ACS Omega
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!