LAUSR

Conventional ion current-based nanopore technique that identify single molecule is hampered by limitations in providing only the ionic cur-rent information. Here we introduce a silver nanotriangle-based nanopore (diameter <50 nm) system for detecting molecule translocation using surface-enhanced Raman scattering (SERS). Rhodamine 6G is used as a model molecule to study the effect of electric field (-1 V) on the mass transport. The four DNA bases also show significantly different SERS signals when they are transported into the plasmonic nanopore. The observations suggest that in the electric field analyte molecules are driven into the nanopipette through the hot spot of the silver nanopore. The plasmonic nanopore shows a great potential as a high-sensitive SERS platform for detecting molecule transport and paves the way for single molecules probing.