LAUSR

Heparin, as a sulfated polysaccharide found in animal tissues, is a commonly employed clinical anticoagulant. However, the heparin concentration in digested raw materials is very low and difficult to recover at high concentrations. To address this issue and enrich the heparin content that can be purified, we have fabricated novel polyamidoamine (PAMAM) dendrimers functionalized on halloysite nanotubes (HNTs), which were also decorated and magnetized with iron oxide (Fe3O4) nanoparticles to enable magnetic separation for selective, scalable recovery of heparin. Using absorption spectroscopy, the heparin recovery efficiency of HNTs and PAMAM-Fe3O4/HNTs was evaluated and compared the results to Amberlite FPA98 Cl, a commercially accessible resin used in heparin extraction. Our results showed that the PAMAM-Fe3O4/HNTs demonstrated higher efficiency of heparin recovery, both in terms of the capacity and rate of adsorption. We also studied the adsorption mechanism of heparin onto the functional amino groups of ...