LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

Phosphine-Catalyzed Intermolecular Acylfluorination of Alkynes via a P(V) Intermediate.

Photo by bermixstudio from unsplash

We report the phosphine-catalyzed intermolecular carbofluorination of alkynes using acyl fluorides as fluorinating reagents. This reaction promises to be a useful method for the synthesis of highly substituted monofluoroalkene derivatives… Click to show full abstract

We report the phosphine-catalyzed intermolecular carbofluorination of alkynes using acyl fluorides as fluorinating reagents. This reaction promises to be a useful method for the synthesis of highly substituted monofluoroalkene derivatives since acyl fluorides can be easily prepared from the corresponding carboxylic acid derivatives and the reaction proceeds under ambient conditions without the need for a transition-metal catalyst. Experimental and computational studies indicate that a five-coordinate fluorophosphorane is involved as the key intermediate in the fluorination step.

Keywords: phosphine catalyzed; catalyzed intermolecular; intermolecular acylfluorination; alkynes via; acylfluorination alkynes

Journal Title: Journal of the American Chemical Society
Year Published: 2020

Link to full text (if available)


Share on Social Media:                               Sign Up to like & get
recommendations!

Related content

More Information              News              Social Media              Video              Recommended



                Click one of the above tabs to view related content.