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A Ni-catalyzed reductive carboxylation of N-substituted aziridines with CO2 at atmospheric pressure is disclosed. The protocol is characterized by its mild conditions, experimental ease, and exquisite chemo- and regioselectivity pattern,… Click to show full abstract
A Ni-catalyzed reductive carboxylation of N-substituted aziridines with CO2 at atmospheric pressure is disclosed. The protocol is characterized by its mild conditions, experimental ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access β-amino acids, important building blocks with considerable potential as peptidomimetics.
Keywords:
carboxylation aziridines;
amino acids;
aziridines route;
catalyzed carboxylation;
carboxylation
Journal Title: Journal of the American Chemical Society
Year Published: 2021
Link to full text (if available)
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Journal Title: Journal of the American Chemical Society
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!