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An enantioselective semisynthesis of (-)-bufospirostenin A is described. The key steps in the synthesis involve use of our proposed biomimetic and diastereoselective photosantonin rearrangement reaction for construction of the 5/7… Click to show full abstract
An enantioselective semisynthesis of (-)-bufospirostenin A is described. The key steps in the synthesis involve use of our proposed biomimetic and diastereoselective photosantonin rearrangement reaction for construction of the 5/7 bicyclic motif, and a Co-catalyzed reversible double-bond isomerization reaction for installing the double bond in the seven-membered ring.
Keywords:
reaction;
semisynthesis bufospirostenin;
photosantonin rearrangement;
rearrangement reaction
Journal Title: Journal of the American Chemical Society
Year Published: 2022
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Journal Title: Journal of the American Chemical Society
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!