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Organoaluminum species promote a smooth nucleophilic substitution at the quaternary carbon stereocenter of stereodefined polysubstituted cyclopropyl methyl phosphate with a complete inversion of configuration, even when more reactive functional groups… Click to show full abstract
Organoaluminum species promote a smooth nucleophilic substitution at the quaternary carbon stereocenter of stereodefined polysubstituted cyclopropyl methyl phosphate with a complete inversion of configuration, even when more reactive functional groups are present. The regio- and diastereoselectivity of the substitution is attributed to the existence of a bicyclobutonium intermediate.
Keywords:
carbon;
quaternary carbon;
carbon stereocenters;
stereocenters quaternary;
construction quaternary;
stereospecific construction
Journal Title: Journal of the American Chemical Society
Year Published: 2022
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Journal Title: Journal of the American Chemical Society
Year Published: 2022
Link to full text (if available)
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recommendations!