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A catalytic approach to intercept the transient HNO for a chemoselective primary amination of arylboronic acids is reported. A phosphetane-based catalyst operating within PIII/PV═O redox cycling is shown to capture… Click to show full abstract
A catalytic approach to intercept the transient HNO for a chemoselective primary amination of arylboronic acids is reported. A phosphetane-based catalyst operating within PIII/PV═O redox cycling is shown to capture HNO, generated in situ by Nef decomposition of 2-nitropropane, to selectively install the primary amino group at aryl Csp2 centers. The method furnishes versatile primary arylamines from arylboronic acid substrates with the preservation of otherwise reactive functional groups.
Keywords:
chemoselective primary;
transient;
primary amination;
hno;
capture
Journal Title: Journal of the American Chemical Society
Year Published: 2022
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Journal Title: Journal of the American Chemical Society
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!