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Regioselective difunctionalization of arenes remains a long-standing challenge in organic chemistry. We report a novel and general Fe/Ti synergistic methodology for regioselective synthesis of various polysubstituted arenes through either E/E'… Click to show full abstract
Regioselective difunctionalization of arenes remains a long-standing challenge in organic chemistry. We report a novel and general Fe/Ti synergistic methodology for regioselective synthesis of various polysubstituted arenes through either E/E' or Nu/E ortho difunctionalizations of arenes. Preliminary results showed that an unprecedented 1,2-Fe/Ti heterobimetallic arylene intermediate bearing two distinct C-M bonds is essential to the regioselective difunctionalization.
Keywords:
difunctionalization;
chemistry;
synergism enabled;
regioselective arene;
enabled regioselective;
arene difunctionalization
Journal Title: Journal of the American Chemical Society
Year Published: 2023
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Journal Title: Journal of the American Chemical Society
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!