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Nickel catalysts of chiral pyrox ligands promoted enantioselective reductive arylation and heteroarylation of aldimines, using directly (hetero)aryl halides and sulfonates. The catalytic arylation can also be conducted with crude aldimines… Click to show full abstract
Nickel catalysts of chiral pyrox ligands promoted enantioselective reductive arylation and heteroarylation of aldimines, using directly (hetero)aryl halides and sulfonates. The catalytic arylation can also be conducted with crude aldimines generated from condensation of aldehydes and azaaryl amines. Mechanistically, density functional theory (DFT) calculations and experiments pointed to an elementary step of 1,4-addition of aryl nickel(I) complexes to N-azaaryl aldimines.
Keywords:
reductive arylation;
arylation;
enantioselective reductive;
arylation heteroarylation;
heteroarylation aldimines
Journal Title: Journal of the American Chemical Society
Year Published: 2023
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Journal Title: Journal of the American Chemical Society
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!