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A method for C(sp3)-C(sp3) cross-coupling of amines is described. Primary amines are converted to 1,2-dialkyldiazenes by treatment with O-nosylhydroxylamines in the presence of atmospheric oxygen. Denitrogenation of the diazenes with… Click to show full abstract
A method for C(sp3)-C(sp3) cross-coupling of amines is described. Primary amines are converted to 1,2-dialkyldiazenes by treatment with O-nosylhydroxylamines in the presence of atmospheric oxygen. Denitrogenation of the diazenes with an iridium photocatalyst then forges the C-C bond. The substrate scope accommodates a broad latitude of functionality, including heteroaromatics and unprotected alcohols and acids.
Keywords:
via photocatalytic;
coupling amines;
cross coupling;
denitrogenation;
amines via
Journal Title: Journal of the American Chemical Society
Year Published: 2023
Link to full text (if available)
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Journal Title: Journal of the American Chemical Society
Year Published: 2023
Link to full text (if available)
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recommendations!