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We report a highly enantioselective CuH-catalyzed Markovnikov hydrosilylation of vinylarenes and vinyl heterocycles. This method has a broad scope and enables both the synthesis of isolable silanes and the conversion… Click to show full abstract
We report a highly enantioselective CuH-catalyzed Markovnikov hydrosilylation of vinylarenes and vinyl heterocycles. This method has a broad scope and enables both the synthesis of isolable silanes and the conversion of crude products to chiral alcohols. Density functional theory calculations support a mechanism proceeding by hydrocupration followed by σ-bond metathesis with a hydrosilane.
Keywords:
markovnikov hydrosilylation;
hydrosilylation vinylarenes;
vinyl heterocycles;
catalyzed markovnikov;
vinylarenes vinyl
Journal Title: Journal of the American Chemical Society
Year Published: 2017
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Journal Title: Journal of the American Chemical Society
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!