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Reductive condensations of alcohols with aldehydes/ketones to generate ethers are catalyzed by a readily accessible thiourea organocatalyst that operates in combination with HCl. 1,1,3,3-tetramethyldisiloxane serves as a convenient reducing reagent.… Click to show full abstract
Reductive condensations of alcohols with aldehydes/ketones to generate ethers are catalyzed by a readily accessible thiourea organocatalyst that operates in combination with HCl. 1,1,3,3-tetramethyldisiloxane serves as a convenient reducing reagent. This strategy is applicable to challenging substrate combinations and exhibits functional group tolerance. Competing reductive homocoupling of the carbonyl component is suppressed.
Keywords:
reductive etherification;
etherification via;
binding catalysis;
via anion;
anion binding
Journal Title: Journal of the American Chemical Society
Year Published: 2017
Link to full text (if available)
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Journal Title: Journal of the American Chemical Society
Year Published: 2017
Link to full text (if available)
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recommendations!