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The total synthesis of seven members of the lapidilectine and grandilodine family of alkaloids has been accomplished in racemic and enantiopure form without protection/deprotection of functional groups. The two key… Click to show full abstract
The total synthesis of seven members of the lapidilectine and grandilodine family of alkaloids has been accomplished in racemic and enantiopure form without protection/deprotection of functional groups. The two key steps, an 8-endo-dig hydroarylation and a 6-exo-trig photoredox cyclization, were catalyzed using gold. A rationale for the formation of the cyclopropane ring of the lundurines is also provided.
Keywords:
pyrroloazocine indole;
synthesis pyrroloazocine;
unified total;
indole alkaloids;
total synthesis;
synthesis
Journal Title: Journal of the American Chemical Society
Year Published: 2018
Link to full text (if available)
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Journal Title: Journal of the American Chemical Society
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!