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A copper complex embedded in the structure of a water-soluble naphthalene diimide has been designed to bind and cleave G-quadruplex DNA. We describe the properties of this ligand, including its… Click to show full abstract
A copper complex embedded in the structure of a water-soluble naphthalene diimide has been designed to bind and cleave G-quadruplex DNA. We describe the properties of this ligand, including its catalytic activity in the generation of ROS. FRET melting, CD, NMR, gel sequencing, and mass spectrometry experiments highlight a unique and unexpected selectivity in cleaving G-quadruplex sequences. This selectivity relies both on the binding affinity and structural features of the targeted G-quadruplexes.
Keywords:
quadruplex nucleic;
selective scissoring;
scissoring molecular;
catalytic selective;
tool quadruplex;
molecular tool
Journal Title: Journal of the American Chemical Society
Year Published: 2018
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Journal Title: Journal of the American Chemical Society
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!