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We describe the 3-iodopropyl acetal moiety as a simple cleavable unit that undergoes acid catalyzed hydrolysis to liberate HI (p Ka ∼ -10) and acrolein stoichiometrically. Integrating this unit into… Click to show full abstract
We describe the 3-iodopropyl acetal moiety as a simple cleavable unit that undergoes acid catalyzed hydrolysis to liberate HI (p Ka ∼ -10) and acrolein stoichiometrically. Integrating this unit into linear and network polymers gives a class of macromolecules that undergo a new mechanism of degradation with an acid amplified, sigmoidal rate. This trigger-responsive self-amplified degradable polymer undergoes accelerated rate of degradation and agent release.
Keywords:
generating self;
self amplifying;
triggered acid;
acid generating;
acid triggered;
self
Journal Title: Journal of the American Chemical Society
Year Published: 2019
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Journal Title: Journal of the American Chemical Society
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!