Photo by bermixstudio from unsplash
An aza analogue of the Rubottom oxidation is reported. This facile transformation takes place at ambient temperature and directly converts silyl enol ethers to the corresponding primary α-aminoketones. The use… Click to show full abstract
An aza analogue of the Rubottom oxidation is reported. This facile transformation takes place at ambient temperature and directly converts silyl enol ethers to the corresponding primary α-aminoketones. The use of hexafluoroisopropanol (HFIP) as the solvent is essential for the success of this reaction. Overall this process is well-suited for the aza-functionalization and derivatization of complex organic molecules.
Keywords:
aza rubottom;
rubottom oxidation;
oxidation synthetic;
primary aminoketones;
synthetic access
Journal Title: Journal of the American Chemical Society
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Journal of the American Chemical Society
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!