LAUSR

The inner region of solid tumors is found to be high-pressure, hypoxic and immunosuppressive, providing a breeding ground for tumor aggressiveness and metastasis. While intratumoral accumulation of nanomedicines combined with immuno-modulation would significantly enhance therapeutic efficacy, such potential is challenged by the compressed environment and distinct heterogeneity of the tumor bulk. By using apoptotic body (AB) as the carrier, we develop an effective and uni-versal intratumoral nanomedicine delivery system for long-lasting remission of tumors. Our results show that the AB-encapsulated nanomedicine (using CpG immunoadjuvant-modified gold-silver nanorods as a model), after intravenous injection, can be specifically phagocytosed by inflammatory Ly-6C+ monocytes, which then actively infiltrate into the tu-mor center via their natural tumor-homing tendency. With integration of AB-facilitated intratumoral accumulation, nano-rod-based photothermal effect and CpG-promoted immunostimulation, this cell-mediated delivery system can not only efficiently ablate primary tumors, but also elicit a potent immunity to prevent tumor from metastasis and recurrence.