LAUSR

Chemoselective reactions are a highly desirable approach to generate well-defined functional macromolecules. Their ex-traordinary efficiency and selectivity enable the development of flawless structures, such as dendrimers, with unprece-dented structure-to-property capacity but with typically tedious synthetic protocols. Here we demonstrate the potency of chemoselective reactions to accomplish sequence-controlled heterolayered dendrimers. An accurate design of bis-MPA monomers with orthogonally complementary moieties and a wisely selected chemical toolbox generated highly complex monodisperse dendrimers through simplified protocols. The versatility of the strategy was proved by obtaining different dendritic families after altering the order of addition of the monomers. Moreover, we evaluated the feasibility of the one-pot approach towards these heterolayered dendrimers as proof-of-concept.