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T cells engineered to home in on brain cancer

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Immunotherapies activate T cells to destroy tumours, but the approach has failed in some brain cancers. A strategy to improve migration of T cells across the blood–brain barrier could overcome… Click to show full abstract

Immunotherapies activate T cells to destroy tumours, but the approach has failed in some brain cancers. A strategy to improve migration of T cells across the blood–brain barrier could overcome this limitation.A synthetic ligand enhances T-cell binding to brain endothelial cells.

Keywords: brain cancer; cells engineered; engineered home; home brain; brain

Journal Title: Nature
Year Published: 2018

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