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A self-activating orphan receptor

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The first 3D structure of a full-length G-protein-coupled receptor whose natural activator is unknown has been determined, providing insights into an unusual mode of activation and a basis for discovering… Click to show full abstract

The first 3D structure of a full-length G-protein-coupled receptor whose natural activator is unknown has been determined, providing insights into an unusual mode of activation and a basis for discovering therapeutics. The structure of an orphan G-protein-coupled receptor.

Keywords: receptor; self activating; activating orphan; orphan receptor

Journal Title: Nature
Year Published: 2020

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