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A receptor that lets dementia-associated tau proteins into neurons

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In many neurodegenerative disorders, the spread of protein aggregates underlies disease progression in the brain. A receptor molecule has now been found that mediates the neuronal uptake of one such… Click to show full abstract

In many neurodegenerative disorders, the spread of protein aggregates underlies disease progression in the brain. A receptor molecule has now been found that mediates the neuronal uptake of one such harmful protein. LRP1 protein mediates propagation of tau in the brain.

Keywords: tau proteins; associated tau; dementia associated; receptor lets; proteins neurons; lets dementia

Journal Title: Nature
Year Published: 2020

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