LAUSR

Prior to the mainstream introduction of corneal collagen cross-linking (CXL) in the late 2000s, there was no effective treatment to prevent progression of keratoconus, other than corneal grafting procedures, which may in some cases just serve to delay progression.1 Over the last 15 years, however, there has been a significant shift in paradigm, with CXL emerging as an effective modality to prevent progression of ectatic disease. Whilst there is a significant body of evidence to support the scientific and clinical outcomes of CXL, we feel it is prudent to be mindful of the risks we expose our patients to, and it is important to be aware that whilst welldesigned protocols do exist for CXL, it is still largely carried out in an unregulated manner.2 The presentation, rate, and end stage of keratoconus can vary greatly between affected individuals, though severity and age at presentation are recognised to be important. The risk factors for development of keratoconus are well described with ethnicity, family history, genetic susceptibility, eye rubbing, and syndromic associations all recognised to contribute to the development of keratoconus. The involvement of eye rubbing is supported by scientific literature, with an underlying hypothesis of trauma induced injury, subsequent involvement of inflammatory mediators in the wound-healing response, and an increased rate of keratocyte apoptosis.3,4 Although progression of keratoconus is generally accepted to be reflected by an increasing steepness of corneal curvature, with attendant reduction in uncorrected visual acuity, no definite criteria for progression of keratoconus currently exist. Whilst in most studies an increase of greater than 1.0 dioptre (D) of keratometry is considered to represent significant progression of keratoconus, we must consider a number of other factors. Topographic artefacts due to contact lens molding must always be avoided where possible, which can be achieved by at least 2 to 3 weeks rest from rigid gas permeable lens wear. Data quality of tomographic and topographic scans should be rigorously checked and the effect of tear film pooling, dryness and blinking should be addressed. Repeatability of topographic indices in keratoconus is recognised to be reduced in comparison to a healthy cornea, and so we should set our criterion of increased keratometry with this in mind.5,6 Certainly, in advanced keratoconus (maximum Keratometry 455 D) keratometric measurements are known to be even less reliable, and in these groups a 42.5 D increase in keratometry is likely to represent a real progressive change.7 Last of all, no consensus exists on decreasing corneal thickness as a criterion for progression detection. Once progression of keratoconus is established, CXL may be offered to a patient. It is not unusual for both children and young adults to undergo immediate CXL at the first diagnosis of keratoconus. The effect of age on progression of keratoconus is uncertain, however, and no firm parameters exist to guide us on when to offer CXL, though an upcoming randomised controlled trial recruiting 10–16-year olds will hopefully shed light on this area. Commitment of patients to regular follow up, and the presence of a corneal graft in the fellow eye may also guide us on when to offer CXL. In addition, the evaluation and treatment of allergic eye disease and habitual eye rubbing should also play a role in the decision-making process. Inability to control itching and stop eye rubbing, especially knuckling, may guide us towards earlier treatment, while it is also very important to control ocular atopy before CXL to reduce complications such as scarring, infection and keratitis.8 While a significant amount of evidence exists for the use of CXL in the treatment of keratoconus, it is still acknowledged that there is C O M M E N T Eye (2018) 32, 4–6 © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved 0950-222X/18