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Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function

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Batf3 is a transcription factor that impacts the development of CD103+ tissue‐resident dendritic cells (DCs). However, whether Batf3 is absolutely required for the development of CD8+ DCs remains controversial. Id2… Click to show full abstract

Batf3 is a transcription factor that impacts the development of CD103+ tissue‐resident dendritic cells (DCs). However, whether Batf3 is absolutely required for the development of CD8+ DCs remains controversial. Id2 is required for CD8+ DC development. Here we show that bone marrow chimeric mice with a deletion of Id2 in the CD11c compartment lose the ability to reject a skin graft expressing a non‐self protein antigen or mount a delayed hypersensitivity response. In contrast, Batf3−/− mice remained competent for skin graft rejection and delayed hypersensitivity, and retained a CD8+ DC population with markers characteristic of the CD11b+ DC lineage, including CD11b, CD4 and CD172α, as well as the key regulator transcription factor IRF4, but lacked IRF8 expression. CD8+ DCs in Batf3−/− mice took up and cleaved protein antigen and larger particles but were unable to phagocytose dying cells, a characteristic feature to the CD8+ DC lineage. These data clarify a requirement for CD8+ lineage DCs to induce effectors of neo‐antigen‐driven skin graft rejection, and improve our understanding of DC subtype commitment by demonstrating that in the absence of Batf3 CD8+ DCs can change their fate and become CD11b+ DCs.

Keywords: cd8; cd8 dcs; skin graft; batf3; cell

Journal Title: Immunology and cell biology
Year Published: 2017

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