LAUSR

approach in a variety of examples involving different viruses and target cells. In one example, they expressed a genetically encoded calcium indicator in single cells in the brain of a mouse and determined the cells’ orientation tuning in response to visual stimuli. In the future, Roska and Müller want to continue developing the technology. Roska thinks that they can further improve the efficiency of the technology and maybe even automate it. Furthermore, he wants to target cells in deeper brain regions without relying on imaging-based guidance. Instead, he thinks about combining the technology with optogenetic identification of target cells, which involves channelrhodopsin expression, illumination and electrical recording from candidate cells before they are targeted by virus stamping. Nina Vogt