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Hexanucleotide repeat expansions in C9orf72 gene locus create double jeopardy, first by leading to DNA–RNA R-loops that spawn double-strand breaks and second by the synthesis of dipeptide repeats that hinder… Click to show full abstract
Hexanucleotide repeat expansions in C9orf72 gene locus create double jeopardy, first by leading to DNA–RNA R-loops that spawn double-strand breaks and second by the synthesis of dipeptide repeats that hinder DNA repair. This two-pronged mechanism may explain neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia.
Keywords:
dna contract;
kill neurons;
loopholes dna;
contract kill
Journal Title: Nature Neuroscience
Year Published: 2017
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Journal Title: Nature Neuroscience
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!