Major Depressive Disorder (MDD) results in significant morbidity, functional impairment, and mortality. By the year 2020, depression is estimated to be second only to heart disease in magnitude of disease… Click to show full abstract
Major Depressive Disorder (MDD) results in significant morbidity, functional impairment, and mortality. By the year 2020, depression is estimated to be second only to heart disease in magnitude of disease burden. Approximately 30–40% of patients with MDD have treatment resistant depression (TRD), which is conventionally defined as a failure to respond to two adequate medication trials or as a relapse during treatment.
               
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