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Rheumatoid arthritis: Modelling cytokine signalling networks

Although an imbalance between proinflammatory and anti-inflammatory cytokines has been implicated in rheumatoid arthritis (RA), the identification of specific cytokines regulating RA pathophysiology is still challenging. Modelling cytokine signalling networks… Click to show full abstract

Although an imbalance between proinflammatory and anti-inflammatory cytokines has been implicated in rheumatoid arthritis (RA), the identification of specific cytokines regulating RA pathophysiology is still challenging. Modelling cytokine signalling networks and evaluating associated pathway activities might facilitate the effective identification of cytokines for treatment and prevention of RA.

Keywords: cytokine signalling; modelling cytokine; arthritis modelling; rheumatoid arthritis; signalling networks

Journal Title: Nature Reviews Rheumatology
Year Published: 2017

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