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Morphine compared to placebo for procedural pain in preterm infants: safety, efficacy and equipoise

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Among nonventilated preterm infants, who are less than 32 weeks of gestation or with birth weight less than 1501 g, undergoing an eye examination to detect retinopathy of prematurity (ROP)… Click to show full abstract

Among nonventilated preterm infants, who are less than 32 weeks of gestation or with birth weight less than 1501 g, undergoing an eye examination to detect retinopathy of prematurity (ROP) or heel lancing, will a 0.1 mg/kg single oral dose of morphine, compared to a placebo solution, be safe, and provide analgesic efficacy demonstrated by Premature Infant Pain Profile-Revised scoring system (PIPP-R) and noxious-evoked brain activity (nEBA) while maintaining physiological stability?

Keywords: morphine compared; efficacy; compared placebo; preterm infants; pain

Journal Title: Journal of Perinatology
Year Published: 2019

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