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Type of feeding provided with dextrose gel impacts hypoglycemia outcomes: comparing donor milk, formula, and breastfeeding

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Examine neonatal hypoglycemia (NH) outcomes based on type of feeding provided with first dextrose gel. Retrospective matched cohort study of 99 infants ≥35 weeks gestational age who received dextrose gel… Click to show full abstract

Examine neonatal hypoglycemia (NH) outcomes based on type of feeding provided with first dextrose gel. Retrospective matched cohort study of 99 infants ≥35 weeks gestational age who received dextrose gel in combination with breastfeeding, formula feeding, or donor milk feeding for NH. The exposure was feeding type. The outcomes were: (1) median change in blood glucose (Δ BG) concentration after first gel, (2) odds of second gel, and (3) odds of recurrent NH. Median Δ BG was greater in formula (17.0 mg/dL) and donor milk (19.0 mg/dL) fed vs. breastfed infants (7.0 mg/dL). Donor milk and formula feeding were both associated with lower odds of second gel and recurrent NH. Associations remained significant in late-preterm infants, but only formula feeding remained significant in full-term infants. Formula and donor milk feedings both raised blood sugar concentrations, but the impact differed by gestational age.

Keywords: milk; feeding; dextrose gel; formula; hypoglycemia outcomes; donor milk

Journal Title: Journal of Perinatology
Year Published: 2020

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