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Role for kappa-opioid system in stress-induced cocaine use uncovered with PET

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1. Jaffe AE, Irizarry RA. Accounting for cellular heterogeneity is critical in epigenomewide association studies. Genome Biol. 2014;15:R31. 2. Zheng SC, Breeze CE, Beck S, Teschendorff AE. Identification of differentially… Click to show full abstract

1. Jaffe AE, Irizarry RA. Accounting for cellular heterogeneity is critical in epigenomewide association studies. Genome Biol. 2014;15:R31. 2. Zheng SC, Breeze CE, Beck S, Teschendorff AE. Identification of differentially methylated cell types in epigenome-wide association studies. Nat Methods. 2018;15:1059–66. 3. Lein E, Borm LE, Linnarsson S. The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing. Science. 2017;358:64–69. 4. Wang X, Allen WE, Wright MA, Sylwestrak EL, Samusik N, Vesuna S, et al. Threedimensional intact-tissue sequencing of single-cell transcriptional states. Science. 2018;361:eaat5691. 5. Burgess DJ. Spatial transcriptomics coming of age. Nat Rev Genet. 2019;20:317. 6. Rodriques SG, Stickels RR, Goeva A, Martin CA, Murray E, Vanderburg CR, et al. Slide-seq: a scalable technology for measuring genome-wide expression at high spatial resolution. Science. 2019;363:1463–7. 7. Ståhl PL, Salmén F, Vickovic S, Lundmark A, Navarro JF, Magnusson J, et al. Visualization and analysis of gene expression in tissue sections by spatial transcriptomics. Science. 2016;353:78–82. 8. Maniatis S, Äijö T, Vickovic S, Braine C, Kang K, Mollbrink A, et al. Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis. Science. 2019;364:89–93. 9. Skene NG, Bryois J, Bakken TE, Breen G, Crowley JJ, Gaspar HA, et al. Genetic identification of brain cell types underlying schizophrenia. Nat Genet. 2018;50:825–33.

Keywords: science; spatial transcriptomics; opioid system; role kappa; cell; kappa opioid

Journal Title: Neuropsychopharmacology
Year Published: 2019

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