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PD1 inhibitor in combination with 5-azacytidine and low-dose DLI for the successful treatment of AML patients who relapsed after transplantation

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Acute myeloid leukaemia (AML) patients who relapse after allogeneic haematopoietic stem cell transplantation (allo-HSCT) have a poor prognosis. The management of AML relapse after allo-HSCT remains a major therapeutic challenge.… Click to show full abstract

Acute myeloid leukaemia (AML) patients who relapse after allogeneic haematopoietic stem cell transplantation (allo-HSCT) have a poor prognosis. The management of AML relapse after allo-HSCT remains a major therapeutic challenge. Here, to the best of our knowledge, we report for the first time a successful treatment based on a programmed death 1 (PD1) inhibitor in combination with 5-azacytidine and low-dose donor lymphocyte infusion (DLI) in two AML patients who relapsed post alloHSCT. Case 1

Keywords: inhibitor combination; pd1 inhibitor; successful treatment; aml patients; transplantation; aml

Journal Title: Bone Marrow Transplantation
Year Published: 2020

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